Kuo-Chen Chou Selected Research

Coronavirus 3C Proteases

9/2019	An insightful recollection since the distorted key theory was born about 23 years ago.
5/2004	Virtual screening for SARS-CoV protease based on KZ7088 pharmacophore points.

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Kuo-Chen Chou Research Topics

Disease

16	Neoplasms (Cancer) 01/2019 - 08/2004
9	Alzheimer Disease (Alzheimer's Disease) 01/2014 - 04/2002
5	Severe Acute Respiratory Syndrome 09/2019 - 08/2003
5	Human Influenza (Influenza) 06/2011 - 07/2009
3	Carcinogenesis 01/2016 - 01/2015
3	Influenza in Birds (Avian Flu) 08/2009 - 10/2007
3	Acquired Immunodeficiency Syndrome (AIDS) 04/2008 - 01/2002
2	Inflammation (Inflammations) 11/2019 - 08/2004
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019 - 08/2002
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2019 - 01/2014
2	Rheumatoid Arthritis 01/2018 - 01/2014
2	Septic Shock (Toxic Shock Syndrome) 01/2018 - 01/2014
2	Schizophrenia (Dementia Praecox) 01/2016 - 06/2004
2	Thrombosis (Thrombus) 01/2016 - 08/2004
2	Chronic Pain 01/2014 - 07/2004
2	Drug-Related Side Effects and Adverse Reactions 01/2013 - 01/2009
2	Colorectal Neoplasms (Colorectal Cancer) 01/2013 - 01/2012
2	Type 2 Diabetes Mellitus (MODY) 01/2013 - 11/2004
2	Infections 01/2012 - 10/2009
1	Glioma (Gliomas) 01/2020
1	Lupus Nephritis 01/2019
1	Carcinoma (Carcinomatosis) 01/2017
1	Coma (Comas) 01/2016
1	Tuberculosis (Tuberculoses) 01/2016
1	Xeroderma Pigmentosum (Kaposi's Disease) 01/2015
1	Melanoma (Melanoma, Malignant) 01/2015
1	Lung Neoplasms (Lung Cancer) 05/2014
1	Osteoporosis 03/2014
1	Dementia (Dementias) 01/2014
1	Epilepsy (Aura) 01/2014
1	Wounds and Injuries (Trauma) 01/2014
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2014
1	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 01/2014
1	Bacterial Infections (Bacterial Infection) 01/2013
1	Malaria 01/2012
1	Pathologic Processes 01/2012
1	Hepatocellular Carcinoma (Hepatoma) 01/2012
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2012
1	Prostatic Neoplasms (Prostate Cancer) 01/2012
1	Fibrosis (Cirrhosis) 01/2012
1	Metabolic Diseases (Metabolic Disease) 10/2011
1	Diabetes Mellitus 10/2011
1	Hepatic Tuberculosis 03/2011
1	Virus Diseases (Viral Diseases) 03/2011
1	Orthomyxoviridae Infections 02/2010
1	Obesity 06/2009
1	Persistent Infection 04/2006

Drug/Important Bio-Agent (IBA)

19	Pharmaceutical PreparationsIBA 01/2017 - 04/2002
14	Proteins (Proteins, Gene)FDA Link 11/2019 - 09/2004
4	Biological ProductsIBA 01/2020 - 07/2004
4	Peptide Hydrolases (Proteases)FDA Link 09/2019 - 08/2003
3	MicroRNAs (MicroRNA)IBA 01/2016 - 01/2015
3	Biomarkers (Surrogate Marker)IBA 01/2013 - 01/2011
3	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2013 - 09/2002
3	rupintrivirIBA 05/2009 - 08/2003
2	EnzymesIBA 09/2019 - 08/2003
2	Coronavirus 3C ProteasesIBA 09/2019 - 05/2004
2	Peptides (Polypeptides)IBA 03/2016 - 05/2013
2	Oseltamivir (Tamiflu)FDA Link 10/2010 - 08/2009
2	Protons (Proton)IBA 02/2010 - 07/2009
2	Neuraminidase (Sialidase)IBA 05/2009 - 10/2007
2	3-(2,4-dimethoxybenzylidene)anabaseineIBA 01/2008 - 09/2007
2	HIV ProteaseIBA 05/2007 - 01/2002
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 09/2004 - 04/2002
1	Abatacept (Orencia)FDA Link 01/2019
1	Terpenes (Terpenoids)IBA 01/2019
1	Tyrosine (L-Tyrosine)FDA Link 01/2018
1	Small Untranslated RNAIBA 06/2017
1	Piwi-Interacting RNAIBA 06/2017
1	Explosive Agents (Explosives)IBA 03/2016
1	CytokinesIBA 01/2016
1	AntithrombinsIBA 01/2016
1	Epidermal Growth Factor (EGF)IBA 01/2015
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 03/2014
1	AcidsIBA 01/2014
1	Conotoxins (Conotoxin)IBA 01/2014
1	Arachidonic Acid (Vitamin F)IBA 01/2014
1	3-nitrotyrosineIBA 01/2014
1	Antifibrinolytic Agents (Antifibrinolytics)IBA 01/2014
1	Apolipoproteins E (ApoE)IBA 01/2014
1	ApolipoproteinsIBA 01/2014
1	Cytochrome P-450 CYP2J2 (CYP2J2)IBA 01/2014
1	Antiviral Agents (Antivirals)IBA 05/2013
1	Therapeutic UsesIBA 01/2013
1	ragaglitazarIBA 01/2013
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2013
1	Prescription DrugsIBA 01/2013
1	Investigational DrugsIBA 01/2013
1	Amino Acids FDA Link 01/2012
1	Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA 01/2012
1	5'-deoxy-5'-thioinosine 5'-monophosphate (ISMP)IBA 01/2012
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 10/2011
1	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 01/2011
1	Amantadine (Aman)FDA LinkGeneric 10/2009
1	Rimantadine FDA LinkGeneric 10/2009
1	alpha7 Nicotinic Acetylcholine ReceptorIBA 05/2009
1	Ligand-Gated Ion ChannelsIBA 05/2009
1	CytochromesIBA 01/2009
1	agaritineIBA 05/2007

Therapy/Procedure

3	Therapeutics 05/2007 - 05/2005